Pancreatic adenocarcinoma is one of the deadliest forms of cancer with no effective therapeutic options.A KRAS mutation can be found in up to 90% of all pancreatic tumors, making it a promising therapeutic target.The introduction of new KRAS inhibitors has Fabrics been a milestone in the history of KRAS mutant tumors; however, therapeutic resistanc
Giardia duodenalis infections are among the most common causes of waterborne diarrhoeal disease worldwide.At the height of infection, G.duodenalis trophozoites induce multiple pathophysiological processes within intestinal epithelial Ceiling Fan cells that contribute to the development of diarrhoeal disease.To date, our understanding of pathophysio
BackgroundScrub typhus, caused by Orientia tsutsugamushi infection, is one of the main causes of febrile illness in the Asia-Pacific region.Although cell-mediated immunity plays an important role in protection, little Prerolled Cones is known about the phenotypic changes and dynamics of leukocytes in scrub typhus patients.Methodology/principal find
The acquisition of movable jaws was a major Tray (Set of 3) event during vertebrate evolution.The role of NK3 homeobox 2 (Nkx3.2) transcription factor in patterning the primary jaw joint of gnathostomes (jawed vertebrates) is well known, however knowledge about its regulatory mechanism is lacking.In this study, we report a proximal enhancer element